Daniel C. Berry
Assistant Professor

Daniel C. Berry

Phone

607-254-8857

Address

Division of Nutritional Sciences
Cornell University
307 Biotechnology Building
Ithaca, NY 14853

Email

Web Sites

Department Profile

Background

Daniel Berry received a B.S. degree from the State University of New York at Cortland in 2005 and a Ph.D. degree from the Department of Nutrition, Case Western Reserve University, in 2011. He was a postdoctoral fellow from June 2012-July 2017 in the Department of Developmental Biology and Division of Endocrinology Department of Internal Medicine at UT Southwestern Medical Center. He joined the Division of Nutritional Sciences at Cornell in July 2017 as an Assistant Professor.

Research Description

Our laboratory focuses on understanding adipose tissue biology and systemic metabolism by studying adipose stem cells (ASC). We specifically examine ASC dynamics, the ASC niche, and the role of ASCs in white adipose tissue development, homeostasis, obesogenic expansion and thermogenesis. Using unique in vivo genetic tools, we can mark, track and manipulate these cells to gain insight into the cellular and molecular biology with the goal to elucidate possible therapies. We focus on identifying factors and nutrients that regulate and mediate ASC-niche communication, and ASC dynamics with the intent to disrupt adipocyte formation but preserve or enhance metabolic health.

Selected Publications

Jiang, Y.,* Berry, D.C.,*† Tang, W., Arpke, R.W., Kyba, M., and Graff, J.M. A PPARϒ transcriptional cascade directs adipose progenitor-niche interaction and niche expansion. Nature Commun.  2017 Jun 26;8:15926. doi: 10.1038/ncomms15926. *Contributed equally. †Co-corresponding author.

Berry, D.C.,† Jiang, Y., Arpke, R.W., Close, E.L., Uchida, A., Reading, D., Berglund, ED., Kyba, M., and Graff, J.M. Cellular aging contributes to failure of cold-induced beige adipocyte formation in old mice and humans. Cell Metab. 2017 Jan 10;25(1):166-181. †Co-corresponding author.

Berry, D.C., Jiang, Y and Graff, J.M. "Emerging roles of adipose progenitor cells in tissue development, homeostasis, expansion and thermogenesis." Trends Endocrinol Metab. 2016, Aug; 27(8): 574-585.

Berry, D.C., Jiang, Y., and Graff, J.M. Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function. Nat Commun. 2016 Jan 5; 7:10184. doi: 10.1038/ncomms10184.

Jiang, Y.,* Berry, D.C.,* Tang, W., and Graff, J.M. Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis. Cell Rep. 2014 Nov 6; 9(3):1007-22. *Contributed equally.

Berry, D.C., Stenesen, D., Zeve, D., Graff, J.M. "The developmental origins of adipose tissue" Development. 2013 Oct; 140(19):3939-49

Berry, D.C., Levi, L., and Noy, N. "Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation". Cancer Res 2014 Nov 1; 74(21):6341-51.

Berry, D. C., Desantis, D., Soltanian, H., Croniger, C.M., and Noy, N. "Retinoic acid upregulates pre-adipocyte genes to block adipogenesis and suppress diet-induced obesity". Diabetes. 2012 May; 61(5): 1112-21.

Berry, D. C., Jin, H., Majumdar, A., and Noy, N. "Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses." Proc Natl Acad Sci USA. 2011 Mar 15; 108(11): 4340-4345.

Berry, D. C., and Noy, N. "All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor." Mol Cell Biol. 2009 Jun; 29(12): 3286-3296.