Angela E. Douglas
Daljit S. and Elaine Sarkaria Professor of Insect Physiology and Toxicology

Angela E. Douglas

Phone

607-255-8539

Address

Department of Entomology
5134 Comstock Hall
Cornell University
Ithaca, NY 14853

Email

Web Sites

Department Profile

Lab Web site

Background

Angela Douglas is the Daljit S. and Elaine Sarkaria Professor of Insect Physiology and Toxicology in the Department of Entomology. She received a B.A. degree from Oxford, UK in 1978 and a Ph.D. from Aberdeen University in 1981. She was a Royal Society University Research Fellow (1985-1996) and Biotechnology and Biological Sciences Research Fellow (2005-8), and was a member of faculty at the University of York, UK (from 1997), before joining the faculty at Cornell in 2008. Dr. Douglas is currently a member of the American Society for Microbiology and fellow of the Entomological Society of America, and Royal Entomological Society of London. Dr. Douglas's research has been supported by the National Institutes of Health, National Science Foundation and the United States Department of Agriculture.

Research Description

All animals are chronically infected with microorganisms, most of which are benign or beneficial to their animal host. We study the three-way interaction between microorganisms and the nutrition and immune function of animals by a combination of genomic and physiological approaches, to understand how the associations between animals and microbial populations evolve and function. Our core questions include: How does the microbiota influence host nutrition, including susceptibility to metabolic disorders? And how are the composition and activities of the microbiota managed by the host immune system? Our research is focused in insects, both as tractable biomedical models for human-microbiome interactions, and to develop novel insect pest control strategies.

Selected Publications

Macdonald SJ, Lin GG, Russell CW, Thomas GH and Douglas AE, 2012. The central role of the host cell in symbiotic nitrogen metabolism. Proceedings of the Royal Society of London B. 279: 2965-73.

Wallace IS, Shakesby AJ, Hwang JH, Choi WG, Martinkova N, Douglas AE and Roberts DM, 2012. Acyrthosiphon pisum AQP2: a multifunctional insect aquaglyceroporin. Biochimica et Biophysica Acta - Biomembranes 1818: 627-635.

Wong CN, Ng P and Douglas AE, 2011. Low diversity bacterial community in the gut of the fruitfly Drosophila melanogaster. Environmental Microbiology 13: 1889-1900.

Poliakov A, Russell CW, Ponnala L, Hoops HJ, Sun Q, Douglas AE and van Wijk KJ, 2011. Large-scale label-free quantitative proteomics of the pea aphid-Buchnera symbiosis. Molecular and Cellular Proteomics 10: M10.007039.

Douglas AE, Bouvaine S and Russell R, 2011. How the insect immune system interacts with an obligate symbiotic bacterium. Proceedings of the Royal Society of London B 278: 333-338.

Douglas AE, 2010. The Symbiotic Habit. Princeton University Press.
Thomas GH, Zucker J, Macdonald AJ, Sorokin A, Goryanin I and Douglas AE, 2009. A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola. BMC Systems Biology 3: 24.

Gündüz EA and Douglas AE 2009. Symbiotic bacteria enable insect to utilise a nutritionally-inadequate diet. Proceedings of the Royal Society of London B. 276: 987-991.