Michael Goldberg
Professor of Genetics

Michael Goldberg

Phone

607-254-4802

Address

Department of Molecular Biology & Genetics
425 Biotechnology Building
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Department Profile

Background

Michael Goldberg, an Professor of Genetics, received a B.S. in Molecular Biophysics and Biochemistry at Yale University in 1973 and a Ph.D. in Biochemistry from Stanford University in 1979. He was a postdoctoral fellow of the Helen Hay Whitney Foundation at the University of Basel, Switzerland, from 1979 to 1981, and at Harvard University from 1981 to 1982. He joined the Cornell faculty in 1982. He is a member of both the Graduate Field of Genetics and Development and Biochemistry, Molecular, and Cell Biology. Dr. Goldberg's research program has been supported by the Swiss National Science Foundation, National Institutes of Health, United States Department of Agriculture, and the Cornell Biotechnology Program. He was a Senior Fellow of the Fogarty International Center in 1989, performing research at Imperial College, London, England. He is a member of the Genetics Society of America,the American Association for the Advancement of Science, and the American Society for Cell Biology, and is currently a member of the Genetics Study Section at the National Institutes of Health. Professor Goldberg teaches BioGD 281.

Research Description

The major focus of our laboratory is the genetic, cytological, and molecular analysis of genes required for the proper segregation of chromosomes to daughter cells during mitosis and meiosis in Drosophila melanogaster. We have identified several such loci by screening collections of mutants for aberrant chromosome cytology. A wide range of phenotypes is represented, including mutations causing aneuploidy, polyploidy, metaphase arrest, endoreduplication of mitotic chromosomes, low mitotic index, and abnormal chromosome morphology.

Selected Publications

The Drosophila kinesin-like protein KLP3A is a midbody component required for central spindle assembly and initiation of cytokinesis. J. Cell Biol. 129:709-723 (1995). With B.C.Williams, M.F. Riedy, E.V. Williams, and M. Gatti.

The Drosophila cofilin-like gene twinstar is required for cytokinesis and centrosome migration. J. Cell Biol. 131:1243-1259 (1995). With K.C. Gunsalus, S. Bonaccorsi, E. Williams, F.Verni, and M. Gatti.

Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation. J. Cell Biology 134:1127-1140 (1996). With B.C. Williams and M. Gatti.

UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior. Genes Develop. 11:863-875 (1997). With G. Cenci, R. Rawson, G. Belloni, D.H., Castrillon, M. Tudor, R. Petrucci, S.A. Wasserman, and M. Gatti.

Click here to view Dr. Goldberg's PubMed listings.