Zhenglong Gu
Assistant Professor

Zhenglong Gu


Fax: 607 255-1033


Division of Nutrition
317 Savage Hall
Cornell University
Ithaca, NY 14853-2703


Web Sites

Department Profile

Lab Website


Research in our lab focuses broadly on the area of RNA biology.  We are taking microarray-based approaches to examine questions both about the mechanism of pre-mRNA splicing, as well as the role of splicing as a control point for regulating gene expression.  We are studying aspects of RNA processing both in the budding yeast Saccharomyces cerevisiae as well as the fission yeast Schizosaccharomyces pombe.

Selected Publications

Wu, W, McCusker, J.H. ?Gu, Z ... Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789. Submitted to Proceedings of the National Academy of Sciences, USA. 2007

Jiang, H, Liu, D, Gu, Z, Wang, W. Rapid evolution in a pair of recent duplicate segments of rice. Exp Zoolog B Mol Dev Evol, 308B, 50-57 (2006)

Gu Z, David L, Petrov D, Jones T, Davis RW, Steinmetz LM. Elevated evolutionary rates in the lab strain of S. cerevisiae. Proceedings of the National Academy of Sciences, USA 2005;102:1092-1097.

Maltsev N, Glass EM, Ovchinnikova G, Gu Z. Molecular mechanisms involved in robustness of yeast central metabolism against null mutations. J Biochem (Tokyo) 2005;137(2):177-187.

Gu Z, Rifkin SA, White KP, Li W-H. Duplicate genes increase expression diversity within and between species. Nature Genetics 2004;36:577-579.

Li W-H, Gu Z, Cavalcanti A, Nekrutenko A. Detection of gene duplications and block duplications in eukaryotic genomes. Journal of Structural and Functional Genomics 2003;3:27-34.

Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, Li W-H. Role of duplicate genes in genetic robustness against null mutations. Nature 2003;421:63-66.

Cavalcanti A, Ferreira R, Gu Z, Li W-H. Patterns of gene duplication in yeast and C. elegans. Journal of Molecular Evolution 2003;56:28-37.

Gu Z, Nicolae D, Lu H-S, Li W-H. Rapid divergence in expression between duplicate genes inferred from microarray gene expression data. Trends in Genetics 2002;18:609-613.

Li, W.-H., Gu, Z., Wang, H., Nekrutenko, A. Evolutionary Analyses of the Human Genome. Nature, 409, 847-849 (2001)

Gu Z, Wang H, Nekrutenko A, Li W-H. Densities, length proportions, and other distributional features of repetitive sequences in the human genome estimated from 430 megabases of genomic sequence. Gene 2000;259:81-88.

Hao L, Gu Z, Dai Z. The frequency distribution and establishment of fruit fly strain of segregation distorter in drosophila melanogaster in China. Acta Genetica Sinica 2000;4:298-303.