Phone

607-254-2881
Fax: 607-255-4698

Address

Department of Biological Statistics and Computational Biology
101 Biotechnology Building
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Lab Web Site
Department Profile

Background

Research Description

My research is focused on understanding the genetics, development, and evolution of complex phenotypes. Research in my group occurs in two major divisions: 1. development of computational inference approaches for mapping loci and modeling pathways, 2. experimental quantitative analysis of genetic pathways in Drosophila. For the first of these, my group is developing approaches that we apply to a wide variety of model organisms including yeast, flies, and humans; the second is our attempt to develop a quantitative understanding of specific pathways in a genetic model system. These are complimentary endeavors and members of the group tend to span these divisions. Current research of group members includes: development of Bayesian approaches for pedigree inference, Bayesian mixture prior approaches for identifying pathway relationships underlying gene expression variation, analysis of regulation in Drosophila reproductive genes, and experimental analysis of signal transduction pathways in Drosophila wing development.

Selected Publications

• Castelhano, M., G.M. Acland, D.F. Antczak, C.B. Bustamante, P. Ciccone, E. Corey, J.G. Mezey, R.L. Page, J. Schimenti, M. Vernier-Singer, and R.J. Todhunter. 2008. A DNA Archive at veterinary teaching hospital to investigate the genetic basis of disease. Journal of the American Veterinary Medical Association. in press.
• Mezey, J.G., S.V. Nuzhdin, F. Ye, and C.D. Jones. 2008. Evolutionary co-expression domains in the Drosophila transcriptome.BMC Evolutionary Biology 8:2.
• Kim, T-S., B.A. Logsdon, S. Park, J.G. Mezey/, and K. Lee. 2007. Quantitative Trait Loci for Circadian Clock Identified in Neurospora crassa. Genetics 177:2335-2347.
• Holloway, A.K., M.K.N. Lawniczak, J.G. Mezey, D.J. Begun, and C.D. Jones. 2007. Adaptive gene expression divergence inferred from molecular population genomics. PLOS Genetics 3:2007-2013.
• Mezey, J.G. and D. Houle. 2005. The dimensionality of genetic variation for wing shape in Drosophila melanogaster. Evolution 59:1027-1038.
• Hahn, M.W., J.G. Mezey, D.J. Begun, J.H. Gillespie, A.D. Kern, C.H. Langley, and L.C. Moyle.2005. Natural Selection and codon bias on single genomes. Nature 433:E5.
• Mezey, J.G. and D. Houle. 2003. Comparing G matrices: why common principal components are informative. Genetics 165:411-425.
• Kim, C., K. Kawasaki, S. Minoshima, C. Amemiya, W. Miller, N. Shimizu, W. Bailey, G.P.Wagner, J.G. Mezey and F. Ruddle. 2000. Hox cluster duplication in the horn shark (Heterodontus francisi) and the vertebrate radiation. Proceedings of the National Academy of Sciences 97:1655-1660.