Students in this area use cutting-edge wet lab and computational methods to understand the functional significance of genome-scale variation and genome organization. For example, some groups in this area are developing sophisticated computational models to understand genome-scale variation of DNA, as well as integrating it with large data sets of phenotypic information. Other groups are identifying and annotating functional elements such as enhancers that impact gene expression.
Research Area Faculty
John Lis, Professor Molecular Biology & Genetics Research Interests: Our research interests focus on molecular mechanisms by which promoters and enhancers regulate gene expression. We use state-of-the-art genome-wide assays and analyses to evaluate the interplay of chromatin architecture and transcription regulation. |
607-255-1983 jtl10@cornell.edu Lab Website |
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Philipp Messer, Assistant Professor Biological Statistics & Computational Biology Research Interests: Population genetics; evolutionary genomics; computational biology |
607-255-3984 pm544@cornell.edu Lab Website Publications |
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Alex Nikitin, Professor of Pathology, Leader of Cornell Stem Cell Program Biomedical Sciences Research Interests: We aim to understand how aberrations in mechanisms governing stem cell niches may lead to cancer in the female reproductive tract, prostate and stomach. Our research approaches include organoid cultures, mouse modeling, and genome modifications. |
607-253-4347 an58@cornell.edu Lab Website Publications |
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Zeribe Nwosu, Assistant Professor Molecular Biology & Genetics Research Interests: Research in the Nwosu Lab focuses on understanding the metabolic alterations that drive cancer, the involvement of tumor microenvironment cells in modulating metabolism, and ways to effectively target metabolism to improve cancer treatment |
zcnwosu@cornell.edu Lab Website Publications |
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Wojtek Pawlowski, Professor School of Integrative Plant Science: Plant Breeding & Genetics School of Integrative Plant Science: Plant Biology Research Interests: Mechanisms and evolution of meiotic recombination; meiosis; evolutionary genomics |
607-254-8745 wp45@cornell.edu Lab Website Publications |
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Joseph Peters, Professor Microbiology Research Interests: Molecular mechanisms of genome stability and evolution; novel transposon targeting mechanisms recognizing DNA replication and RNA-based systems utilizing CRISPR/Cas |
607-255-2271 jep48@cornell.edu Lab Website Publications |
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Jeffrey Pleiss, Associate Professor Molecular Biology & Genetics Research Interests: Translational regulation, RNA modification, genetic recoding |
607-254-8562 jap332@cornell.edu Lab Website Publications |
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Frank Pugh, Professor Research Interests: We study molecular mechanisms of enhancer-promoter communication in humans and yeast, involving genome-wide ChIP-exo/seq and computational (AI) techniques. From cancer to condensates. |
607-255-2203 fp265@cornell.edu Lab Website Publications |
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Shu-Bing Qian, James Jamison Professor Division of Nutritional Sciences Research Interests: RNA biology, translational regulation, protein quality control |
607-254-3397 sq38@cornell.edu Lab Website Publications |
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Adrienne Roeder, Associate Professor School of Integrative Plant Science: Plant Biology Research Interests: Plant cell biology, plant development, morphogenesis, growth, and patterning of Arabidopsis flowers and leaves, engineered living materials |
607-255-4467 ahr75@cornell.edu Lab Website Publications |
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Brian Rudd, Associate Professor Microbiology & Immunology Research Interests: Development and function of the immune system |
607-253-3400 bdr54@cornell.edu Lab Website Publications |
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John Schimenti, Professor Biomedical Sciences Molecular Biology & Genetics Research Interests: Dr. Schimenti’s lab studies the genetics of fertility, development, and genome maintenance in mice. Specific projects concern germline development and genetic quality control; the relationship between genomic instability, inflammation and cancer; and modeling human disease alleles in mice. |
607-253-3636 jcs92@cornell.edu Lab Website Publications |
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Praveen Sethupathy, Associate Professor Biomedical Sciences Research Interests: Role of non-coding RNAs (in particular microRNAs) in genetic, microbial, dietary, and environmental control of health and disease, primarily in diabetes, dyslipidemia, gastrointestinal (GI) disorders including Crohn’s disease, and liver/GI cancers |
607-253-4375 pr46@cornell.edu Lab Website |
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Ayshwarya Subramanian, Assistant Professor Molecular Biology & Genetics Research Interests: The focus of my research is understanding the principles governing cellular heterogeneity, crosstalk, and evolution in the context of human tissues and disease. |
607-255-8790 as3894@cornell.edu Lab Website Publications |
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Xinzhu April Wei, Assistant Professor Computational Biology Research Interests: We develop more accurate and scalable computational methods that utilize massive genomic datasets to gain new insights into fundamental evolutionary processes, such as demographic history, natural selection, complex traits evolution, and gene conversion. |
607-255-0873 xw583@cornell.edu Lab Website Publications |